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Objective  To investigate the association between common transforming growth factor beta ( TGF-β ) single nucleotide polymorphisms (SNP) and significant complications of coronary heart disease (CHD).    Method  We performed a meta-analysis of published case-control studies assessing the association of  TGF-β  SNPs with a range of CHD complications. A random effects model was used to calculate odds ratios and confidence intervals. Analyses were conducted for additive, dominant and recessive modes of inheritance.    Results  Six studies involving 5535 cases and 2970 controls examining the association of common SNPs in  TGF-β1  with CHD were identified. Applying a dominant model of inheritance, three  TGF-β1  SNPs were significantly associated with CHD complications: The T alleles of  rs1800469  (OR = 1.125, 95% CI 1.016–1.247, p = 0.031) and  rs1800470  (OR = 1.146, 95% CI 1.026–1.279, p = 0.021); and the C allele of  rs1800471  (OR = 1.207, 95% CI 1.037–1.406, p = 0.021).    Conclusion  This meta-analysis suggests that common genetic polymorphisms in  TGF-β1  are associated with complications of CHD.

Meta-Analysis of the Association between Transforming Growth Factor-Beta Polymorphisms and Complications of Coronary Heart Disease