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The seven WhiB proteins of  Mycobacterium tuberculosis  ( M.tb ) are widely believed to be redox-sensing transcription factors due to their binding of iron-sulfur clusters and similarities to DNA binding proteins. Here, we explored the nature of this hypothesized relationship. We exposed  M.tb  to physiologic conditions such as gradual hypoxia, nitric oxide (NO), cyclic AMP and  in vivo  conditions, and measured transcription of the  whiB  genes. We found  whiB3  to be induced both by hypoxia and NO,  whiB7  to be induced in macrophage-like cells, and  whiB4  to be induced in mouse lung. Cyclic AMP induced  whiB1,−2, −4, −6  and  −7 . Our data indicate that the  M.tb whiB  genes are induced independently by various stimuli which may add versatility to their suggested redox-sensing properties.

Gene Expression of Mycobacterium tuberculosis Putative Transcription Factors whiB1-7 in Redox Environments