Transient Phenomena in Gene Expression after Induction of Transcription | Zendy

Carlus Deneke | Zendy; Sophia Rudorf | Zendy; Angelo Valleriani | Zendy

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Transient Phenomena in Gene Expression after Induction of Transcription

Author(s) -

Carlus Deneke,

Sophia Rudorf,

Angelo Valleriani

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0035044

Subject(s) - polysome , gene expression , messenger rna , gene , transcription (linguistics) , biology , regulation of gene expression , microbiology and biotechnology , genetics , ribosome , rna , linguistics , philosophy

When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.

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