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We recently associated ovarian  FMR1 genotypes and sub-genotypes with distinct ovarian aging patterns. How they impact older females is, however, unknown. We, therefore, investigated 217 consecutive first  in vitro  fertilization (IVF) cycles in women >40 assessing oocyte yields, stratified for better (anti-Müllerian hormone, AMH >1.05 ng/mL) or poorer (AMH≤1.05 ng/mL) functional reserve (FOR)). Mean age was 42.4±2.0 years, mean AMH 0.76±0.92 ng/mL and mean oocyte yield 5.3±5.4. Overall, and in women with better FOR,  FMR1  did not affect oocyte yields. With poorer FOR (AMH≤1.05 ng/mL) women with  het-norm/high , however, demonstrated higher oocyte yields (5.0±3.8) than those with  het-norm/low  sub-genotype 3.1±2.5; P = 0.03), confirmed after log conversion. Known associated with low FOR at young age,  het-norm/high , thus, appears to preserve FOR into older age, and both  het  sub-genotypes appear to expand female reproductive lifespan into opposite directions.

The Impact in Older Women of Ovarian FMR1 Genotypes and Sub-Genotypes on Ovarian Reserve