Discovery and Genomic Characterization of Noroviruses from a Gastroenteritis Outbreak in Domestic Cats in the US | Zendy

Pierfrancesco Pinto | Zendy; Qiuhong Wang | Zendy; Ning Chen | Zendy; Edward J. Dubovi | Zendy; Joshua B. Daniels | Zendy; Laurie M. Millward | Zendy; Canio Buonavoglia | Zendy; Vito Martella | Zendy; Linda J. Saif | Zendy

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Discovery and Genomic Characterization of Noroviruses from a Gastroenteritis Outbreak in Domestic Cats in the US

Author(s) -

Pierfrancesco Pinto,

Qiuhong Wang,

Ning Chen,

Edward J. Dubovi,

Joshua B. Daniels,

Laurie M. Millward,

Canio Buonavoglia,

Vito Martella,

Linda J. Saif

Publication year - 2012

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0032739

Subject(s) - feline calicivirus , norovirus , caliciviridae , virology , capsid , calicivirus , biology , outbreak , cats , genotype , virus , genetics , medicine , gene

Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8–12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs: lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species.

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