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vasa  is a highly conserved RNA helicase involved in animal germ cell development. Among vertebrate species, it is typically present as a single copy per genome. Here we report the isolation and sequencing of BAC clones for Nile tilapia  vasa  genes. Contrary to a previous report that Nile tilapia have a single copy of the  vasa  gene, we find evidence for at least three  vasa  gene loci. The  vasa  gene locus was duplicated from the original site and integrated into two distant novel sites. For one of these insertions we find evidence that the duplication was mediated by a circular DNA intermediate. This mechanism of gene duplication may explain the origin of isolated gene duplicates during the evolution of fish genomes. These data provide a foundation for studying the role of multiple  vasa  genes in the development of tilapia gonads, and will contribute to investigations of the molecular mechanisms of sex determination and evolution in cichlid fishes.

Circular DNA Intermediate in the Duplication of Nile Tilapia vasa Genes