Small Protein-Mediated Quorum Sensing in a Gram-Negative Bacterium | Zendy

Sang-Wook Han | Zendy; Malinee Sriariyanun | Zendy; Sang-Won Lee | Zendy; Manoj K. Sharma | Zendy; Ofir Bahar | Zendy; Zachary Bower | Zendy; Pamela C. Ronald | Zendy

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Small Protein-Mediated Quorum Sensing in a Gram-Negative Bacterium

Author(s) -

Sang-Wook Han,

Malinee Sriariyanun,

Sang-Won Lee,

Manoj K. Sharma,

Ofir Bahar,

Zachary Bower,

Pamela C. Ronald

Publication year - 2011

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0029192

Subject(s) - xanthomonas oryzae , quorum sensing , biology , xanthomonas , microbiology and biotechnology , virulence , gram negative bacteria , bacteria , genetics , biofilm , pathogen , gene , escherichia coli

The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY S 22, derived from the Ax21 ( a ctivator of X A 21 -mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae . Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.

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