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The heterodimeric Ku complex has been shown to participate in DNA repair and telomere regulation in a variety of organisms. Here we report a detailed characterization of the function of Ku70 in the diploid fungal pathogen  Candida albicans . Both  ku70  heterozygous and homozygous deletion mutants have a wild-type colony and cellular morphology, and are not sensitive to MMS or UV light. Interestingly, we observed complex effects of  KU70  gene dosage on telomere lengths, with the  KU70/ku70  heterozygotes exhibiting slightly shorter telomeres, and the  ku70  null strain exhibiting long and heterogeneous telomeres. Analysis of combination mutants suggests that the telomere elongation in the  ku70  null mutant is due mostly to unregulated telomerase action. In addition, elevated levels of extrachromosomal telomeric circles were detected in the null mutant, consistent with activation of aberrant telomeric recombination. Altogether, our observations point to multiple mechanisms of the Ku complex in telomerase regulation and telomere protection in  C. albicans , and reveal interesting similarities and differences in the mechanisms of the Ku complex in disparate systems.

The Candida albicans Ku70 Modulates Telomere Length and Structure by Regulating Both Telomerase and Recombination