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An intracellular plant pathogen ‘ Candidatus  Liberibacter asiaticus,’ a member of the  Rhizobiales , is related to  Sinorhizobium meliloti ,  Bradyrhizobium japonicum , nitrogen fixing endosymbionts,  Agrobacterium tumefaciens , a plant pathogen, and  Bartonella henselae , an intracellular mammalian pathogen. Whole chromosome comparisons identified at least 50 clusters of conserved orthologous genes found on the chromosomes of all five metabolically diverse species. The intracellular pathogens ‘ Ca . Liberibacter asiaticus’ and  Bartonella henselae  have genomes drastically reduced in gene content and size as well as a relatively low content of guanine and cytosine. Codon and amino acid preferences that emphasize low guanosine and cytosine usage are globally employed in these genomes, including within regions of microsynteny and within signature sequences of orthologous proteins. The length of orthologous proteins is generally conserved, but not their isoelectric points, consistent with extensive amino acid substitutions to accommodate selection for low GC content. The ‘ Ca . Liberibacter asiaticus’ genome apparently has all of the genes required for DNA replication present in  Sinorhizobium meliloti  except it has only two, rather than three RNaseH genes. The gene set required for DNA repair has only one rather than ten DNA ligases found in  Sinorhizobium meliloti , and the DNA PolI of ‘ Ca . Liberibacter asiaticus’ lacks domains needed for excision repair. Thus the ability of ‘ Ca . Liberibacter asiaticus’ to repair mutations in its genome may be impaired. Both ‘ Ca . Liberibacter asiaticus and  Bartonella henselae  lack enzymes needed for the metabolism of purines and pyrimidines, which must therefore be obtained from the host. The ‘ Ca . Liberibacter asiaticus’ genome also has a greatly reduced set of sigma factors used to control transcription, and lacks sigma factors 24, 28 and 38. The ‘ Ca . Liberibacter asiaticus’ genome has all of the hallmarks of a reduced genome of a pathogen adapted to an intracellular lifestyle.

Comparison of the ‘Ca. Liberibacter asiaticus’ Genome Adapted for an Intracellular Lifestyle with Other Members of the Rhizobiales