Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice | Zendy

Timo A. Immel | Zendy; Ulrich Groth | Zendy; Thomas Huhn | Zendy; Peter Öhlschläger | Zendy

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Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice

Author(s) -

Timo A. Immel,

Ulrich Groth,

Thomas Huhn,

Peter Öhlschläger

Publication year - 2011

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0017869

Subject(s) - in vivo , titanium , in vitro , chemistry , hydrolysis , combinatorial chemistry , cancer research , biophysics , biochemistry , biology , organic chemistry , genetics

The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo . From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.

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