A Folding Pathway-Dependent Score to Recognize Membrane Proteins | Zendy

Hamid HadiAlijanvand | Zendy; Maryam Rouhani | Zendy; Elizabeth A. Proctor | Zendy; Nikolay V. Dokholyan | Zendy; Ali Akbar Moosavi–Movahedi | Zendy

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A Folding Pathway-Dependent Score to Recognize Membrane Proteins

Author(s) -

Hamid HadiAlijanvand,

Maryam Rouhani,

Elizabeth A. Proctor,

Nikolay V. Dokholyan,

Ali Akbar Moosavi–Movahedi

Publication year - 2011

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0016778

Subject(s) - membrane protein , colocalization , folding (dsp implementation) , membrane , biophysics , protein subcellular localization prediction , ion channel , protein folding , computational biology , biology , chemistry , microbiology and biotechnology , bioinformatics , biochemistry , gene , engineering , electrical engineering , receptor

While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP 3 mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP 3 mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.

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