The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1 | Zendy

Bjørn A. Nexø | Zendy; Tove Christensen | Zendy; Jette Lautrup Frederiksen | Zendy; Anné Møller-Larsen | Zendy; Annette Oturai | Zendy; Palle Villesen | Zendy; Bettina Hansen | Zendy; Kari Konstantin Nissen | Zendy; Magdalena Janina Laska | Zendy; Trine Skov Petersen | Zendy; Sandra Bonnesen | Zendy; Anne Hedemand | Zendy; Tingting Wu | Zendy; Xinjie Wang | Zendy; Xiuqing Zhang | Zendy; Tomasz Brudek | Zendy; Romana Maric | Zendy; Helle Bach Søndergaard | Zendy; Finn Sellebjerg | Zendy; Klaus Brusgaard | Zendy; Anders L. Kjeldbjerg | Zendy; Henrik B. Rasmussen | Zendy; Anders Lade Nielsen | Zendy; Mette Nyegaard | Zendy; Thor Petersen | Zendy; Anders D. Børglum | Zendy; Finn Skou Pedersen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

Author(s) -

Bjørn A. Nexø,

Tove Christensen,

Jette Lautrup Frederiksen,

Anné Møller-Larsen,

Annette Oturai,

Palle Villesen,

Bettina Hansen,

Kari Konstantin Nissen,

Magdalena Janina Laska,

Trine Skov Petersen,

Sandra Bonnesen,

Anne Hedemand,

Tingting Wu,

Xinjie Wang,

Xiuqing Zhang,

Tomasz Brudek,

Romana Maric,

Helle Bach Søndergaard,

Finn Sellebjerg,

Klaus Brusgaard,

Anders L. Kjeldbjerg,

Henrik B. Rasmussen,

Anders Lade Nielsen,

Mette Nyegaard,

Thor Petersen,

Anders D. Børglum,

Finn Skou Pedersen

Publication year - 2011

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0016652

Subject(s) - multiple sclerosis , endogenous retrovirus , single nucleotide polymorphism , gene , biology , locus (genetics) , retrovirus , genetics , allele , virology , genotype , immunology , genome

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research