Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life | Zendy

Peter Rzehak | Zendy; Carel Thijs | Zendy; Marie Standl | Zendy; Monique Mommers | Zendy; Claudia Glaser | Zendy; Eugène Jansen | Zendy; Norman Klopp | Zendy; Gerard H. Koppelman | Zendy; Paula Singmann | Zendy; Dirkje S. Postma | Zendy; Stefanie Sausenthaler | Zendy; Pieter C. Dagnelie | Zendy; Piet A. van den Brandt | Zendy; Berthold Koletzko | Zendy; Joachim Heinrich | Zendy

Open Access

Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life

Author(s) -

Peter Rzehak,

Carel Thijs,

Marie Standl,

Monique Mommers,

Claudia Glaser,

Eugène Jansen,

Norman Klopp,

Gerard H. Koppelman,

Paula Singmann,

Dirkje S. Postma,

Stefanie Sausenthaler,

Pieter C. Dagnelie,

Piet A. van den Brandt,

Berthold Koletzko,

Joachim Heinrich

Publication year - 2010

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0013261

Subject(s) - fads2 , polyunsaturated fatty acid , single nucleotide polymorphism , biology , population , gene cluster , genetics , medicine , physiology , fatty acid , genotype , docosahexaenoic acid , gene , biochemistry , environmental health

Background Association of genetic-variants in the FADS1-FADS2 -gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS -gene-cluster and blood-fatty-acid-composition with eczema was studied. Methods and Principal Findings Data of two population-based-birth-cohorts in the Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS -gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort. Conclusions and Significance PUFA-composition in young children's blood is under strong control of the FADS -gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data.

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