Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice | Zendy

Petter Brodin | Zendy; Tadepally Lakshmikanth | Zendy; Ramit Mehr | Zendy; Maria H. Johansson | Zendy; Adil Doganay Duru | Zendy; Adnane Achour | Zendy; Mali SalmonDivon | Zendy; Klas Kärre | Zendy; Petter Höglund | Zendy; SvenErik Johansson | Zendy

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Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

Author(s) -

Petter Brodin,

Tadepally Lakshmikanth,

Ramit Mehr,

Maria H. Johansson,

Adil Doganay Duru,

Adnane Achour,

Mali SalmonDivon,

Klas Kärre,

Petter Höglund,

SvenErik Johansson

Publication year - 2010

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0013174

Subject(s) - mhc class i , biology , major histocompatibility complex , cd8 , receptor , mhc restriction , microbiology and biotechnology , cd1 , immunology , immune system , interleukin 21 , genetics

A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack, but may at the same time develop NK cell sensitivity, due to failure to express inhibitory ligands for Ly49 receptors. The extent of MHC class I downregulation needed on normal cells to trigger NK cell effector functions is not known.

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