Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite | Zendy

Kate L. Tomlinson | Zendy; Gareth Davies | Zendy; Daniel Sutton | Zendy; Roger Palframan | Zendy

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Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite

Author(s) -

Kate L. Tomlinson,

Gareth Davies,

Daniel Sutton,

Roger Palframan

Publication year - 2010

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0013136

Subject(s) - house dust mite , medicine , immunology , methacholine , inflammation , asthma , aeroallergen , cytokine , airway resistance , interleukin , lung , respiratory disease , allergy , allergen

Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have investigated the role of the cytokine interleukin-13 (IL-13) in the generation and persistence of airway cellular inflammation, bronchial remodeling and deterioration in airway function in a model of allergic asthma caused by chronic exposure to the aeroallergen House Dust Mite (HDM).

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