Open AccessGenetic and Molecular Functional Characterization of Variants within TNFSF13B, a Positional Candidate Preeclampsia Susceptibility Gene on 13q
Author(s) -
Mona Høysæter Fenstad,
Matthew P. Johnson,
Linda T. Roten,
Per A.,
Siri Forsmo,
Kjetil Klepper,
Christine East,
Lawrence J. Abraham,
John Blangero,
Shaun P. Brennecke,
Rigmor Austgulen,
Eric K. Moses
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0012993
Subject(s) - genetics , candidate gene , single nucleotide polymorphism , linkage disequilibrium , tag snp , positional cloning , biology , genetic association , genetic linkage , haplotype , snp , preeclampsia , allele , gene , genotype , pregnancy , locus (genetics)
Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We have adopted a positional cloning approach to identify maternal genetic components, with linkages previously demonstrated to chromosomes 2q, 5q and 13q in an Australian/New Zealand familial cohort. The current study aimed to identify potential functional and structural variants in the positional candidate gene TNFSF13B under the 13q linkage peak and assess their association status with maternal preeclampsia genetic susceptibility.
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