Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease | Zendy

Tao Ma | Zendy; Charles A. Hoeffer | Zendy; Estibaliz CapetilloZarate | Zendy; Fangmin Yu | Zendy; Helen Wong | Zendy; Michael T. Lin | Zendy; Davide Tampellini | Zendy; Eric Klann | Zendy; Robert D. Blitzer | Zendy; Gunnar K. Gouras | Zendy

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Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

Author(s) -

Tao Ma,

Charles A. Hoeffer,

Estibaliz CapetilloZarate,

Fangmin Yu,

Helen Wong,

Michael T. Lin,

Davide Tampellini,

Eric Klann,

Robert D. Blitzer,

Gunnar K. Gouras

Publication year - 2010

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0012845

Subject(s) - long term potentiation , pi3k/akt/mtor pathway , synaptic plasticity , neuroscience , gsk 3 , biology , hippocampal formation , microbiology and biotechnology , signal transduction , biochemistry , receptor

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and β-amyloid (Aβ)-induced synaptic dysfunction, which is considered to be critical in the pathogenesis of Alzheimer's disease (AD).

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