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The model filamentous fungus  Neurospora crassa  has been studied for over fifty years and many temperature-sensitive mutants have been generated. While most of these have been mapped genetically, many remain anonymous. The mutation in the  N. crassa  temperature-sensitive lethal mutant  un-7  was identified by a complementation based approach as being in the open reading frame designated NCU00651 on linkage group I. Other mutations in this gene have been identified that lead to a temperature-sensitive morphological phenotype called  png-1 . The mutations underlying  un-7  result in a serine to phenylalanine change at position 273 and an isoleucine to valine change at position 390, while the mutation in  png-1  was found to result in a serine to leucine change at position 279 although there were other conservative changes in this allele. The overall morphology of the strain carrying the  un-7  mutation is compared to strains carrying the  png-1  mutation and these mutations are evaluated in the context of other temperature-sensitive mutants in Neurospora.

Characterization of the Temperature-Sensitive Mutations un-7 and png-1 in Neurospora crassa