Open AccessPlasma Levels of Inter-α Inhibitor Proteins in Children with Acute Dengue Virus Infection
Author(s) -
Penelope Koraka,
YowPin Lim,
Michael D. Shin,
Tatty E. Setiati,
Albert T.A. Mairuhu,
Eric C. M. Van Gorp,
Augustinus Soemantri,
Albert D. M. E. Osterhaus,
B Martina
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0009967
Subject(s) - dengue fever , dengue virus , coagulopathy , biomarker , virology , immunoassay , protease inhibitor (pharmacology) , medicine , immunology , virus , biology , viral load , antibody , biochemistry , antiretroviral therapy
Background Inter-α inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker. Methods and Findings Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls. Conclusions This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.
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