Open AccessNew Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study
Author(s) -
Masahiro Nakajima,
Atsushi Takahashi,
Ikuyo Kou,
Cristina RodriguezFontenla,
Juan J. GómezReino,
Tatsuya Furuichi,
Jin Dai,
Akihiro Sudo,
Atsumasa Uchida,
Naoshi Fukui,
Michiaki Kubo,
Naoyuki Kamatani,
Tatsuhiko Tsunoda,
Κonstantinos Ν. Malizos,
Aspasia Tsezou,
Antonio González,
Yusuke Nakamura,
Shiro Ikegawa
Publication year - 2010
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0009723
Subject(s) - single nucleotide polymorphism , genetics , genome wide association study , gene , genetic association , human leukocyte antigen , biology , osteoarthritis , genome , genotype , medicine , pathology , antigen , alternative medicine
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10 −8 for rs7775228 and 6.73×10 −8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
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