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We have recently identified the membranotropic regions of the hepatitis C virus proteins  E1 ,  E2 ,  core  and  p7  proteins by observing the effect of protein-derived peptide libraries on model membrane integrity. We have studied in this work the ability of selected sequences of these proteins to modulate the L β -L α  and L α -H II  phospholipid phase transitions as well as check the viability of using both DSC and SAXD to screen a protein-derived peptide library. We demonstrate that it is feasible to screen a library of peptides corresponding to one or several proteins by both SAXD and DSC. This methodological combination should allow the identification of essential regions of membrane-interacting proteins which might be implicated in the molecular mechanism of membrane fusion and/or budding.

Screening a Peptide Library by DSC and SAXD: Comparison with the Biological Function of the Parent Proteins