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Background  Acquisition of virulence factors and antibiotic resistance by many clinically important bacteria can be traced to horizontal gene transfer (HGT) between related or evolutionarily distant microflora. Comparative genomic analysis has become an important tool for identifying HGT DNA in emerging pathogens. We have adapted the multi-genome alignment tool  EvoPrinter  to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements.    Principal Findings    EvoPrinter  analysis of 13 different  Staphylococcus aureus  genomes revealed that one of the human isolates, the hospital epidemic methicillin-resistant MRSA252 strain, uniquely shares multiple putative HGT DNA sequences with different causative agents of bovine mastitis that are not found in the other human  S. aureus  isolates. MRSA252 shares over 14 different DNA sequence blocks with the bovine mastitis ET3  S. aureus  strain RF122, and many of the HGT DNAs encode virulence factors.  EvoPrinter  analysis of the MRSA252 chromosome also uncovered virulence-factor encoding HGT events with the genome of  Listeria monocytogenes  and a  Staphylococcus saprophyticus  associated plasmid. Both bacteria are also causal agents of contagious bovine mastitis.    Conclusions    EvoPrinter  analysis reveals that the human MRSA252 strain uniquely shares multiple DNA sequence blocks with different causative agents of bovine mastitis, suggesting that HGT events may be occurring between these pathogens. These findings have important implications with regard to animal husbandry practices that inadvertently enhance the contact of human and livestock bacterial pathogens.

Horizontal Gene Transfers Link a Human MRSA Pathogen to Contagious Bovine Mastitis Bacteria