Open AccessCis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
Author(s) -
Hiroki Nagai,
Guojun Sheng
Publication year - 2007
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0000703
Subject(s) - gene , biology , transcription (linguistics) , genetics , haematopoiesis , globin , locus (genetics) , beta (programming language) , microbiology and biotechnology , stem cell , philosophy , linguistics , computer science , programming language
Chicken beta globin locus contains four genes, two of which, rho and epsilon , are expressed from the earliest stage of primitive hematopoiesis. Here we show that the transcription of these two genes in the nucleus engages in “on/off” phases. During each “on” phase, cotranscription of rho and epsilon in cis is favored. We propose that these two chicken beta globin genes are transcribed not by competing for a transcription initiation complex, but in a cooperative way.
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