Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B | Zendy

Gloria Morizot | Zendy; Romain Jouffroy | Zendy; Albert Faye | Zendy; Paul Chabert | Zendy; Katia Belhouari | Zendy; Ruxandra Câlin | Zendy; Caroline Charlier | Zendy; Patrick Miailhes | Zendy; JeanYves Siriez | Zendy; Oussama Mouri | Zendy; Hélène Yera | Zendy; Jacques Gilquin | Zendy; Roland Tubiana | Zendy; Fanny Lanternier | Zendy; MarieFrance Mamzer | Zendy; Christophe Legendre | Zendy; D. Peyramond | Zendy; Éric Caumes | Zendy; Olivier Lortholary | Zendy; Pierre Buffet | Zendy

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Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B

Author(s) -

Gloria Morizot,

Romain Jouffroy,

Albert Faye,

Paul Chabert,

Katia Belhouari,

Ruxandra Câlin,

Caroline Charlier,

Patrick Miailhes,

JeanYves Siriez,

Oussama Mouri,

Hélène Yera,

Jacques Gilquin,

Roland Tubiana,

Fanny Lanternier,

MarieFrance Mamzer,

Christophe Legendre,

D. Peyramond,

Éric Caumes,

Olivier Lortholary,

Pierre Buffet

Publication year - 2016

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0004304

Subject(s) - visceral leishmaniasis , medicine , amphotericin b , adverse effect , leishmaniasis , leishmania , intensive care medicine , antifungal , antimony , pharmacology , immunology , dermatology , parasite hosting , world wide web , computer science , materials science , metallurgy

We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.

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