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Background  Vector-borne transmission of  Trypanosoma cruzi  is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand  T .  cruzi  infection and vector control, however, much less is known about the burden of infection and epidemiology in northern Peru.    Methodology  A cross-sectional study was conducted to estimate the seroprevalence of  T .  cruzi  infection in humans (n=611) and domestic animals [dogs (n=106) and guinea pigs (n=206)] in communities of Cutervo Province, Peru. Sampling and diagnostic strategies differed according to species. An entomological household study (n=208) was conducted to identify the triatomine burden and species composition, as well as the prevalence of  T .  cruzi  in vectors. Electrocardiograms (EKG) were performed on a subset of participants (n=90  T .  cruzi  infected participants and 170 age and sex-matched controls). The seroprevalence of  T .  cruzi  among humans, dogs, and guinea pigs was 14.9% (95% CI: 12.2 – 18.0%), 19.8% (95% CI: 12.7- 28.7%) and 3.3% (95% CI: 1.4 – 6.9%) respectively. In one community, the prevalence of  T .  cruzi  infection was 17.2% (95% CI: 9.6 - 24.7%) among participants < 15 years, suggesting recent transmission. Increasing age, positive triatomines in a participant's house, and ownership of a  T .  cruzi  positive guinea pig were independent correlates of  T .  cruzi  infection. Only one species of triatomine was found,  Panstrongylus lignarius , formerly  P .  herreri . Approximately forty percent (39.9%, 95% CI: 33.2 - 46.9%) of surveyed households were infested with this vector and 14.9% (95% CI: 10.4 - 20.5%) had at least one triatomine positive for  T .  cruzi . The cardiac abnormality of right bundle branch block was rare, but only identified in seropositive individuals.    Conclusions  Our research documents a substantial prevalence of  T .  cruzi  infection in Cutervo and highlights a need for greater attention and vector control efforts in northern Peru.

Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru