A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever | Zendy

W. Weise | Zendy; Meghan E. Hermance | Zendy; Naomi L. Forrester | Zendy; Alexandra Adams | Zendy; Rose M. Langsjoen | Zendy; Rodion Gorchakov | Zendy; Eryu Wang | Zendy; Maria D. H. Alcorn | Zendy; Konstantin A. Tsetsarkin | Zendy; Scott C. Weaver | Zendy

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A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

Author(s) -

W. Weise,

Meghan E. Hermance,

Naomi L. Forrester,

Alexandra Adams,

Rose M. Langsjoen,

Rodion Gorchakov,

Eryu Wang,

Maria D. H. Alcorn,

Konstantin A. Tsetsarkin,

Scott C. Weaver

Publication year - 2014

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0002969

Subject(s) - virology , attenuated vaccine , yellow fever , dengue fever , alphavirus , biology , vaccination , dengue virus , virus , immunology , dengue vaccine , medicine , virulence , genetics , gene

Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.

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