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The aim of this study was to explore the mechanisms of resistance against invading  Ascaris suum  larvae in pigs. Pigs received a low dose of 100  A. suum  eggs daily for 14 weeks. This resulted in a >99% reduction in the number of larvae that could migrate through the host after a challenge infection of 5000  A. suum  eggs, compared to naïve pigs. Histological analysis at the site of parasite entry, i.e. the caecum, identified eosinophilia, mastocytosis and goblet cell hyperplasia. Increased local transcription levels of genes for IL5, IL13, eosinophil peroxidase and eotaxin further supported the observed eosinophil influx. Further analysis showed that eosinophils degranulated  in vitro  in response to contact with infective  Ascaris  larvae in the presence of serum from both immune and naïve animals. This effect was diminished with heat-inactivated serum, indicating a complement dependent mechanism. Furthermore, eosinophils were efficient in killing the larvae  in vitro  when incubated together with serum from immune animals, suggesting that  A. suum  specific antibodies are required for efficient elimination of the larvae. Together, these results indicate an important role for eosinophils in the intestinal defense against invading  A. suum  larvae.

A Role for Eosinophils in the Intestinal Immunity against Infective Ascaris suum Larvae