Corticosteroid Use for Paradoxical Reactions during Antibiotic Treatment for Mycobacterium ulcerans | Zendy

N. Deborah Friedman | Zendy; Anthony McDonald | Zendy; Michael E. Robson | Zendy; D. O’Brien | Zendy

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Corticosteroid Use for Paradoxical Reactions during Antibiotic Treatment for Mycobacterium ulcerans

Author(s) -

N. Deborah Friedman,

Anthony McDonald,

Michael E. Robson,

D. O’Brien

Publication year - 2012

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0001767

Subject(s) - mycobacterium ulcerans , buruli ulcer , antimicrobial , medicine , debridement (dental) , antibiotics , infectious disease (medical specialty) , antibiotic therapy , pharmacotherapy , dermatology , disease , surgery , biology , microbiology and biotechnology

Buruli or Bairnsdale Ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans and is characterized by necrotic cutaneous lesions. Infection is challenging to treat, and the ideal combination of surgery and antimicrobial therapy continues to evolve. M. ulcerans has been endemic to the Bellarine peninsula in Victoria, Australia, since 1998, with more than 250 cases of infection. Studies have illustrated the safety and efficacy of antimicrobial therapy [1]–[5], and our standard treatment practice has evolved over the last 15 years to comprise limited surgical debridement with combination antimicrobial therapy.

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