Metabolomics-Based Discovery of Diagnostic Biomarkers for Onchocerciasis | Zendy

Judith R. Denery | Zendy; Ashlee A. K. Nunes | Zendy; Mark S. Hixon | Zendy; Tobin J. Dickerson | Zendy; Kim D. Janda | Zendy

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Metabolomics-Based Discovery of Diagnostic Biomarkers for Onchocerciasis

Author(s) -

Judith R. Denery,

Ashlee A. K. Nunes,

Mark S. Hixon,

Tobin J. Dickerson,

Kim D. Janda

Publication year - 2010

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0000834

Subject(s) - onchocerciasis , neglected tropical diseases , onchocerca volvulus , biomarker , biomarker discovery , metabolomics , tropical disease , disease , computational biology , medicine , biology , bioinformatics , immunology , pathology , proteomics , biochemistry , gene

Development of robust, sensitive, and reproducible diagnostic tests for understanding the epidemiology of neglected tropical diseases is an integral aspect of the success of worldwide control and elimination programs. In the treatment of onchocerciasis, clinical diagnostics that can function in an elimination scenario are non-existent and desperately needed. Due to its sensitivity and quantitative reproducibility, liquid chromatography-mass spectrometry (LC-MS) based metabolomics is a powerful approach to this problem.

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