Open AccessIn Vivo Imaging of Schistosomes to Assess Disease Burden Using Positron Emission Tomography (PET)
Author(s) -
Nicolas Salem,
Jason D. Balkman,
Jing Wang,
David L. Wilson,
Zhenghong Lee,
Christopher L. King,
James P. Basilion
Publication year - 2010
Publication title -
plos neglected tropical diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.99
H-Index - 135
eISSN - 1935-2735
pISSN - 1935-2727
DOI - 10.1371/journal.pntd.0000827
Subject(s) - schistosoma mansoni , positron emission tomography , schistosoma , schistosomiasis , in vivo , preclinical imaging , molecular imaging , parasitic disease , helminthiasis , biology , eggs per gram , medicine , physiology , pathology , immunology , nuclear medicine , disease , helminths , microbiology and biotechnology
Schistosomes are chronic intravascular helminth parasites of humans causing a heavy burden of disease worldwide. Diagnosis of schistosomiasis currently requires the detection of schistosome eggs in the feces and urine of infected individuals. This method unreliably measures disease burden due to poor sensitivity and wide variances in egg shedding. In vivo imaging of schistosome parasites could potentially better assess disease burden, improve management of schistosomiasis, facilitate vaccine development, and enhance study of the parasite's biology. Schistosoma mansoni (S. mansoni) have a high metabolic demand for glucose. In this work we investigated whether the parasite burden in mice could be assessed by positron emission tomography (PET) imaging with 2-deoxy-2[(18)F]fluoro-D-glucose (FDG).
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