Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection | Zendy

Jiali Wang | Zendy; Junlei Zhang | Zendy; Wei Chen | Zendy; Xiao-Feng Xu | Zendy; Na Gao | Zendy; Dongying Fan | Zendy; Jing An | Zendy

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Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Author(s) -

Jiali Wang,

Junlei Zhang,

Wei Chen,

Xiao-Feng Xu,

Na Gao,

Dongying Fan,

Jing An

Publication year - 2010

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0000809

Subject(s) - rac1 , actin , actin cytoskeleton , microbiology and biotechnology , biology , actin remodeling , cytoskeleton , gtpase , mdia1 , rhoa , signal transduction , cell , biochemistry

Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant element of endothelial barrier function regulation and has been implicated in the regulation of actin remodeling and intercellular junction formation. Yet there is little evidence linking Rac1 GTPase to alteration in endothelial cell function induced by DV infection.

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