Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa | Zendy

Bouke C. de Jong | Zendy; Martín Antonio | Zendy; Sébastien Gagneux | Zendy

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Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa

Author(s) -

Bouke C. de Jong,

Martín Antonio,

Sébastien Gagneux

Publication year - 2010

Publication title -

plos neglected tropical diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.99

H-Index - 135

eISSN - 1935-2735

pISSN - 1935-2727

DOI - 10.1371/journal.pntd.0000744

Subject(s) - tuberculosis , mycobacterium tuberculosis , sensu stricto , mycobacterium tuberculosis complex , biology , evolutionary biology , zoology , medicine , pathology

Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum , describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.

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