Open AccessMetabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
Author(s) -
Peter Würtz,
Qin Wang,
Antti J. Kangas,
Rebecca C. Richmond,
Joni Skarp,
Mika Tiainen,
Tuulia Tynkkynen,
Pasi Soininen,
Aki S. Havulinna,
Marika Kaakinen,
Jorma Viikari,
Markku J. Savolainen,
Mika Kähönen,
Terho Lehtimäki,
Satu Männistö,
Stefan Blankenberg,
Tanja Zeller,
Jaana Laitinen,
Anneli Pouta,
Pekka Mäntyselkä,
Mauno Vanhala,
Paul Elliott,
Kirsi H. Pietiläinen,
Samuli Ripatti,
Veikko Salomaa,
Olli T. Raitakari,
MarjoRiitta Järvelin,
George Davey Smith,
Mika AlaKorpela
Publication year - 2014
Publication title -
plos medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.847
H-Index - 228
eISSN - 1549-1676
pISSN - 1549-1277
DOI - 10.1371/journal.pmed.1001765
Subject(s) - mendelian randomization , body mass index , metabolite , medicine , obesity , physiology , population , metabolome , endocrinology , metabolomics , interquartile range , biology , bioinformatics , genetics , environmental health , genetic variants , gene , genotype
In this study, Wurtz and colleagues investigated to what extent elevated body mass index (BMI) within the normal weight range has causal influences on the detailed systemic metabolite profile in early adulthood using Mendelian randomization analysis. Please see later in the article for the Editors' Summary
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