Open AccessSystematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project
Author(s) -
Hope L. Johnson,
Maria Deloria Knoll,
Orin S. Levine,
Sonia Stoszek,
Laura Freimanis Hance,
Richard Reithinger,
Larry R. Muenz,
Katherine L. O’Brien
Publication year - 2010
Publication title -
plos medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.847
H-Index - 228
eISSN - 1549-1676
pISSN - 1549-1277
DOI - 10.1371/journal.pmed.1000348
Subject(s) - serotype , pneumococcal disease , incidence (geometry) , medicine , epidemiology , pneumococcal conjugate vaccine , streptococcus pneumoniae , pneumococcal infections , vaccination , disease burden , conjugate vaccine , disease , pediatrics , virology , immunology , biology , immunization , antibiotics , microbiology and biotechnology , antibody , physics , optics
Approximately 800,000 children die each year due to pneumococcal disease and >90% of these deaths occur in developing countries where few children have access to life-saving serotype-based vaccines. Understanding the serotype epidemiology of invasive pneumococcal disease (IPD) among children is necessary for vaccine development and introduction policies. The aim of this study was to systematically estimate the global and regional distributions of serotypes causing IPD in children <5 years of age.
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