Open AccessPotential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data
Author(s) -
Takeshi Azuma,
Gefeng Zhu,
Haiying Xu,
A. Rietz,
Charles G. Drake,
Eric L. Matteson,
Lieping Chen
Publication year - 2009
Publication title -
plos medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.847
H-Index - 228
eISSN - 1549-1676
pISSN - 1549-1277
DOI - 10.1371/journal.pmed.1000166
Subject(s) - rheumatoid arthritis , immunology , arthritis , pathogenesis , medicine , antibody , immune system , autoantibody , autoimmune disease , biology
Finding an association between soluble B7-H4 and rheumatoid arthritis severity, Lieping Chen and colleagues use a mouse model to show that the soluble form blocks the inhibitory function of cell-surface B7-H4.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom