Can Prenatal Malaria Exposure Produce an Immune Tolerant Phenotype?: A Prospective Birth Cohort Study in Kenya | Zendy

Indu Malhotra | Zendy; Arlene E. Dent | Zendy; Peter Mungai | Zendy; Alex Wamachi | Zendy; John H. Ouma | Zendy; David L. Narum | Zendy; Eric M. Muchiri | Zendy; Daniel J. Tisch | Zendy; Christopher L. King | Zendy

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Can Prenatal Malaria Exposure Produce an Immune Tolerant Phenotype?: A Prospective Birth Cohort Study in Kenya

Author(s) -

Indu Malhotra,

Arlene E. Dent,

Peter Mungai,

Alex Wamachi,

John H. Ouma,

David L. Narum,

Eric M. Muchiri,

Daniel J. Tisch,

Christopher L. King

Publication year - 2009

Publication title -

plos medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.847

H-Index - 228

eISSN - 1549-1676

pISSN - 1549-1277

DOI - 10.1371/journal.pmed.1000116

Subject(s) - malaria , immunology , immune system , cord blood , plasmodium falciparum , medicine , prospective cohort study , pregnancy , antigen , biology , genetics

In a prospective cohort study of newborns residing in a malaria holoendemic area of Kenya, Christopher King and colleagues find a subset of children born to malaria-infected women who acquire a tolerant phenotype, which persists into childhood and is associated with increased susceptibility to malarial infection and anemia.

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