Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease | Zendy

Kittipong Maneechotesuwan | Zendy; Xin Yao | Zendy; Kazuhiro Ito | Zendy; Elen Jazrawi | Zendy; Omar S. Usmani | Zendy; Ian M. Adcock | Zendy; Peter J. Barnes | Zendy

Open Access

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

Author(s) -

Kittipong Maneechotesuwan,

Xin Yao,

Kazuhiro Ito,

Elen Jazrawi,

Omar S. Usmani,

Ian M. Adcock,

Peter J. Barnes

Publication year - 2009

Publication title -

plos medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.847

H-Index - 228

eISSN - 1549-1676

pISSN - 1549-1277

DOI - 10.1371/journal.pmed.1000076

Subject(s) - corticosteroid , mechanism of action , phosphorylation , medicine , mechanism (biology) , immunology , action (physics) , disease , biology , genetics , in vitro , philosophy , physics , epistemology , quantum mechanics

Peter Barnes and colleagues show that corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that suppress Th2 cytokine expression. This novel mechanism of corticosteroid action may help explain the efficacy of corticosteroids in allergic diseases.

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