Derivation of Multipotent Mesenchymal Precursors from Human Embryonic Stem Cells | Zendy

Tiziano Barberi | Zendy; Lucy M. Willis | Zendy; Nicholas D. Socci | Zendy; Lorenz Studer | Zendy

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Derivation of Multipotent Mesenchymal Precursors from Human Embryonic Stem Cells

Author(s) -

Tiziano Barberi,

Lucy M. Willis,

Nicholas D. Socci,

Lorenz Studer

Publication year - 2005

Publication title -

plos medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.847

H-Index - 228

eISSN - 1549-1676

pISSN - 1549-1277

DOI - 10.1371/journal.pmed.0020161

Subject(s) - embryonic stem cell , mesenchymal stem cell , microbiology and biotechnology , stem cell , mesoderm , biology , multipotent stem cell , regenerative medicine , stem cell transplantation for articular cartilage repair , cellular differentiation , adult stem cell , clinical uses of mesenchymal stem cells , genetics , progenitor cell , gene

Background Human embryonic stem cells provide access to the earliest stages of human development and may serve as a source of specialized cells for regenerative medicine. Thus, it becomes crucial to develop protocols for the directed differentiation of embryonic stem cells into tissue-restricted precursors. Methods and Findings Here, we present culture conditions for the derivation of unlimited numbers of pure mesenchymal precursors from human embryonic stem cells and demonstrate multilineage differentiation into fat, cartilage, bone, and skeletal muscle cells. Conclusion Our findings will help to elucidate the mechanism of mesoderm specification during embryonic stem cell differentiation and provide a platform to efficiently generate specialized human mesenchymal cell types for future clinical applications.

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