The Roles of Arabidopsis CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs | Zendy

Zhenfei Sun | Zendy; Tongtong Guo | Zendy; Yin Liu | Zendy; Qi Liu | Zendy; Yuda Fang | Zendy

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The Roles of Arabidopsis CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs

Author(s) -

Zhenfei Sun,

Tongtong Guo,

Yin Liu,

Qi Liu,

Yuda Fang

Publication year - 2015

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1005598

Subject(s) - biology , microrna , dicer , repressor , rna polymerase ii , arabidopsis , promoter , transcription factor , transcription (linguistics) , genetics , regulation of gene expression , microbiology and biotechnology , drosha , activator (genetics) , gene , transcriptional regulation , gene expression , rna interference , rna , linguistics , philosophy , mutant

The precise regulation of microRNA (miRNA) transcription and processing is important for eukaryotic development. Plant miRNAs are first transcribed as stem-loop primary miRNAs (pri-miRNAs) by RNA polymerase II,then cleaved in the nucleus into mature miRNAs by Dicer-like 1 (DCL1). We identified a cycling DOF transcription factor, CDF2, which interacts with DCL1 and regulates the accumulation of a population of miRNAs. CDF2 binds directly to the promoters of some miRNAs and works as a transcription activator or repressor for these miRNA genes. CDF2 binds preferentially to the pri-miRNAs regulated by itself and affects DCL1-mediated processing of these pri-miRNAs. Genetically, CDF2 works in the same pathway as miR156 or miR172 to control flowering. We conclude that CDF2 regulates a group of pri-miRNAs at both the transcriptional and posttranscriptional levels to maintain proper levels of their mature miRNAs to control plant development.

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