Epigenetic Regulation by Heritable RNA | Zendy

Reinhard Liebers | Zendy; Minoo Rassoulzadegan | Zendy; Frank Lyko | Zendy

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Epigenetic Regulation by Heritable RNA

Author(s) -

Reinhard Liebers,

Minoo Rassoulzadegan,

Frank Lyko

Publication year - 2014

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1004296

Subject(s) - biology , epigenetics , genetics , mendelian inheritance , phenotype , rna , inheritance (genetic algorithm) , gene , regulation of gene expression , omim : online mendelian inheritance in man , computational biology , non coding rna , epigenesis , non mendelian inheritance , long non coding rna , genome , gene expression , dna methylation , mitochondrial dna

Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance patterns provides a direct challenge to this view and suggests an important role for alternative mechanisms of gene regulation and inheritance. Over the past few years, a highly complex and diverse network of noncoding RNAs has been discovered. Research in animal models has shown that RNAs can be inherited and that RNA methyltransferases can be important for the transmission and expression of modified phenotypes in the next generation. We discuss possible mechanisms of RNA-mediated inheritance and the role of these mechanisms for human health and disease.

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