Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci | Zendy

Yunkun Dang | Zendy; Liande Li | Zendy; Wei Guo | Zendy; Zhihong Xue | Zendy; Yi Liu | Zendy

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Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci

Author(s) -

Yunkun Dang,

Liande Li,

Wei Guo,

Zhihong Xue,

Yi Liu

Publication year - 2013

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1003761

Subject(s) - biology , rna directed dna methylation , dna methylation , genetics , epigenetics of physical exercise , epigenomics , epigenetics , histone methylation , neurospora crassa , gene , gene expression , mutant

Cytosine methylation of DNA is an important epigenetic gene silencing mechanism in plants, fungi, and animals. In the filamentous fungus Neurospora crassa , nearly all known DNA methylations occur in transposon relics and repetitive sequences, and DNA methylation does not depend on the canonical RNAi pathway. disiRNAs are Dicer-independent small non-coding RNAs that arise from gene-rich part of the Neurospora genome. Here we describe a new type of DNA methylation that is associated with the disiRNA loci. Unlike the known DNA methylation in Neurospora , disiRNA loci DNA methylation (DLDM) is highly dynamic and is regulated by an on/off mechanism. Some disiRNA production appears to rely on pol II directed transcription. Importantly, DLDM is triggered by convergent transcription and enriched in promoter regions. Together, our results establish a new mechanism that triggers DNA methylation.

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