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Mouse  Ikbkap  gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized. We used a loss-of-function approach in mice to demonstrate that  Ikbkap  is essential for meiosis during spermatogenesis. Absence of  Ikbkap  results in defects in synapsis and meiotic recombination, both of which result in increased apoptosis and complete arrest of gametogenesis. In  Ikbkap- mutant testes, a few meiotic genes are down-regulated, suggesting IKAP's role in transcriptional regulation. In addition,  Ikbkap -mutant testes exhibit defects in wobble uridine tRNA modification, supporting a conserved tRNA modification function from yeast to mammals. Thus, our study not only reveals a novel function of IKAP in meiosis, but also suggests that IKAP contributes to this process partly by exerting its effect on transcription and tRNA modification.

Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression