The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate | Zendy

Sandra Blanco | Zendy; Agata Kurowski | Zendy; Jennifer Nichols | Zendy; Fiona M. Watt | Zendy; Salvador Aznar Benitah | Zendy; Michaela Frye | Zendy

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The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

Author(s) -

Sandra Blanco,

Agata Kurowski,

Jennifer Nichols,

Fiona M. Watt,

Salvador Aznar Benitah,

Michaela Frye

Publication year - 2011

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1002403

Subject(s) - biology , stem cell , microbiology and biotechnology , cellular differentiation , methyltransferase , stem cell theory of aging , epigenetics , rna , methylation , genetics , progenitor cell , stem cell factor , gene

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.

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