Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations | Zendy

Emiko Noguchi | Zendy; Hiromi Sakamoto | Zendy; Tomomitsu Hirota | Zendy; Kaori Ochiai | Zendy; Yoshimasa Imoto | Zendy; Masafumi Sakashita | Zendy; Fumitake Kurosaka | Zendy; Akira Akasawa | Zendy; Shigemi Yoshihara | Zendy; Noriko Kanno | Zendy; Yumi Yamada | Zendy; Naoki Shimojo | Zendy; Yoichi Kohno | Zendy; Yoichi Suzuki | Zendy; MiJin Kang | Zendy; JiWon Kwon | Zendy; SooJong Hong | Zendy; Ken Inoue | Zendy; Yu-ichi Goto | Zendy; Fumio Yamashita | Zendy; Takashi Asada | Zendy; Hiroshi Hirose | Zendy; Ikuo Saito | Zendy; Shigeharu Fujieda | Zendy; Nobuyuki Hizawa | Zendy; Tohru Sakamoto | Zendy; Hironori Masuko | Zendy; Yusuke Nakamura | Zendy; Ichiro Nomura | Zendy; Mayumi Tamari | Zendy; Tadao Arinami | Zendy; Teruhiko Yoshida | Zendy; Hirohisa Saito | Zendy; Kenji Matsumoto | Zendy

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Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

Author(s) -

Emiko Noguchi,

Hiromi Sakamoto,

Tomomitsu Hirota,

Kaori Ochiai,

Yoshimasa Imoto,

Masafumi Sakashita,

Fumitake Kurosaka,

Akira Akasawa,

Shigemi Yoshihara,

Noriko Kanno,

Yumi Yamada,

Naoki Shimojo,

Yoichi Kohno,

Yoichi Suzuki,

MiJin Kang,

JiWon Kwon,

SooJong Hong,

Ken Inoue,

Yu-ichi Goto,

Fumio Yamashita,

Takashi Asada,

Hiroshi Hirose,

Ikuo Saito,

Shigeharu Fujieda,

Nobuyuki Hizawa,

Tohru Sakamoto,

Hironori Masuko,

Yusuke Nakamura,

Ichiro Nomura,

Mayumi Tamari,

Tadao Arinami,

Teruhiko Yoshida,

Hirohisa Saito,

Kenji Matsumoto

Publication year - 2011

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1002170

Subject(s) - linkage disequilibrium , genome wide association study , single nucleotide polymorphism , biology , genetics , asthma , odds ratio , genetic association , locus (genetics) , snp , human leukocyte antigen , allele , genotype , immunology , gene , medicine , antigen

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations ( P <1×10 −8 ) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1 , was consistently associated with pediatric asthma in 3 independent populations ( P combined = 2.3×10 −10 , odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901 , which were in strong linkage disequilibrium, were strongly associated with pediatric asthma ( DPA1*0201 : P = 5.5×10 −10 , OR = 1.52, and DPB1* 0901: P = 2.0×10 −7 , OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

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