Genetical Genomics: Spotlight on QTL Hotspots | Zendy

Rainer Breitling | Zendy; Yang Li | Zendy; Bruno Tesson | Zendy; Jingyuan Fu | Zendy; Chunlei Wu | Zendy; Tim Wiltshire | Zendy; A.M. Gerrits | Zendy; Leonid Bystrykh | Zendy; Gerald de Haan | Zendy; Andrew I. Su | Zendy; Ritsert C. Jansen | Zendy

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Genetical Genomics: Spotlight on QTL Hotspots

Author(s) -

Rainer Breitling,

Yang Li,

Bruno Tesson,

Jingyuan Fu,

Chunlei Wu,

Tim Wiltshire,

A.M. Gerrits,

Leonid Bystrykh,

Gerald de Haan,

Andrew I. Su,

Ritsert C. Jansen

Publication year - 2008

Publication title -

plos genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.587

H-Index - 233

eISSN - 1553-7404

pISSN - 1553-7390

DOI - 10.1371/journal.pgen.1000232

Subject(s) - biology , genomics , quantitative trait locus , genetics , computational biology , evolutionary biology , genome , gene

Genetical genomics aims at identifying quantitative trait loci (QTLs) for molecular traits such as gene expression or protein levels (eQTL and pQTL, respectively). One of the central concepts in genetical genomics is the existence of hotspots [1], where a single polymorphism leads to widespread downstream changes in the expression of distant genes, which are all mapping to the same genomic locus. Several groups have hypothesized that many genetic polymorphisms—e.g., in major regulators or transcription factors—would lead to large and consistent biological effects that would be visible as eQTL hotspots.

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