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I wish to comment on a paper recently published in the Journal of Neuroscience [1] and relate this paper to one previously published in PLOS Computational Biology [2]. In [1] and [2] among other results, a power law relationship was discovered in a measure of magnetoencephalography (MEG) intra-areal synchronization: the distribution of phase-locking intervals (PLI). However, in [1] the authors also show that the same PLI power law measure cannot distinguish between human MEG and empty MEG scanner data, suggesting that the measure is vulnerable to artefact.  This is important because the first description of the PLI power law methodology, as well as its application to MEG and functional magnetic resonance imaging (fMRI) data, was published in PLOS Computational Biology [2]. The senior author of [2] is also an author of [1]. The results obtained with the PLI methodology published in [2] were presented as evidence for broadband criticality of human brain network synchronization because the PLI method (which applies a threshold to MEG/fMRI data and returns a power law) will also return a power law distribution for PLIs when applied to a model system of Kuramoto oscillators tuned to a critical phase transition. However, it should be noted in this regard that a recent modelling study indicates that power laws also emerge when PLI is applied to noncritical Kuramoto oscillators, and caution is needed when interpreting power laws derived from time series data passed through a threshold [3].  The paper published in PLOS Computational Biology [2] has received multiple citations, and the PLI methodology has been further applied to human neurophysiological data in other studies. From its use, claims have been made about changes in broadband criticality during disease states, e.g., epilepsy [4].  I am concerned that the results presented in [1] indicate that the methodology described in [2] may be unsound and therefore should not be used for inferring criticality of human brain network synchronisation. The presentation of the empty MEG scanner results in [1] is not sufficiently explicit in this sense, and it should have been made much clearer that the influential PLI power law methodology presented in [2] might be problematic.  Science of course moves forward through a process of exploration and correction, and the initial idea presented in PLOS Computational Biology [2] was exciting and innovative; however, the authors should reconsider the interpretation of their findings in light of the empty MEG scanner data. I feel it is therefore important to bring these papers and their conflicting results to the attention of the readers of PLOS Computational Biology and I would ask that the authors of [1,2] clarify the discrepancy in between their data sets and publish an erratum in PLOS Computational Biology if a conflict exists.

plos computational biology/plos computational biology

Comment on “Broadband Criticality of Human Brain Network Synchronization” by Kitzbichler MG, Smith ML, Christensen SR, Bullmore E (2009) PLoS Comput Biol 5: e1000314