Chapter 11: Genome-Wide Association Studies | Zendy

William S. Bush | Zendy; Jason H. Moore | Zendy

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Chapter 11: Genome-Wide Association Studies

Author(s) -

William S. Bush,

Jason H. Moore

Publication year - 2012

Publication title -

plos computational biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.628

H-Index - 182

eISSN - 1553-7358

pISSN - 1553-734X

DOI - 10.1371/journal.pcbi.1002822

Subject(s) - genome wide association study , genetic association , genetic architecture , computational biology , genome , data science , biology , computer science , genetics , single nucleotide polymorphism , quantitative trait locus , genotype , gene

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.

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