Open AccessDestabilizing DNA during Rejoining Enhances Fidelity of Repair
Author(s) -
Richard Robinson
Publication year - 2015
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1002214
Subject(s) - biology , dna repair , dna , duplex (building) , microbiology and biotechnology , replication protein a , genetics , dna mismatch repair , biophysics , computational biology , dna binding protein , gene , transcription factor
A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.
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