Open AccessCalorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous
Author(s) -
Szu-Chieh Mei,
Charles Brenner
Publication year - 2015
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1002048
Subject(s) - longevity , biology , nad+ kinase , calorie restriction , yeast , nicotinamide mononucleotide , intracellular , microbiology and biotechnology , genetics , nicotinamide , biochemistry , enzyme , nicotinamide adenine dinucleotide , endocrinology
Calorie-restriction extends lifespan in many multicellular organisms; here substances secreted by calorie-restricted yeast are found to induce longer life in other yeast cells, suggesting that cellular communication is a component of this phenomenon even in a single-celled organism.
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