Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation | Zendy

Kurt Vermeire | Zendy; Thomas W. Bell | Zendy; Victor Van Puyenbroeck | Zendy; Anne Giraut | Zendy; Sam Noppen | Zendy; Sandra Liekens | Zendy; Dominique Schols | Zendy; Enno Hartmann | Zendy; KaiUwe Kalies | Zendy; Mark Marsh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

Author(s) -

Kurt Vermeire,

Thomas W. Bell,

Victor Van Puyenbroeck,

Anne Giraut,

Sam Noppen,

Sandra Liekens,

Dominique Schols,

Enno Hartmann,

KaiUwe Kalies,

Mark Marsh

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1002011

Subject(s) - sec61 , translocon , endoplasmic reticulum , biology , signal peptide , microbiology and biotechnology , signal recognition particle , ribosome , transmembrane protein , transport protein , protein targeting , membrane protein , biochemistry , peptide sequence , receptor , rna , membrane , gene

A small chemical drug CADA specifically binds to the signal peptide of the membrane pre-protein CD4, disturbing its synthesis, impeding the routing to and expression on the cell surface.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research